“ … If you run Index Server (Cisvc.exe), then Index Server may rescan the Temporary ASP.NET Files directory while it requests a Microsoft ASP.NET page. Cisvc.exe then holds a lock on the Temporary ASP.NET Files directory for one to five minutes. The length of time of the lock depends on the size of the directory that causes the Aspnet_wp.exeprocess (or W3wp.exe process for applications that run on Microsoft Internet Information Services [IIS] 6.0) to not load the particular DLL. …”
http://support.microsoft.com/default.aspx?scid=kb;en-us;329065
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